-
News
-
Subscribe to EP newsletter
New Test & Measurement DealersSelect All
-
- Buy
- Sell
- Industry Directory
- Apps
- Test & Measurement
-
Analyzers
-
Oscilloscope
-
Meters
-
Generators
-
DC Power Supply
-
Optical Communications
-
Other Test Equipment
-
Accessories
-
Probes
-
Software
-
AC Power Sources
-
Accessory Kits
-
Amplifiers
-
Antenna
- View All Categories >>
-
- Semiconductor & PCB
-
Front End
-
Back End
-
PC Board Assembly
- View All Categories >>
-
- Surplus & Liquidation
- Computers & Electronics
- Construction
-
Aggregate Equipment
-
Air Compressors
-
Asphalt / Pavers / Concrete Equipment
-
Compactors
-
Cranes
-
Crawler Loaders
-
Dozers
-
Drills
-
Dumpers
-
Excavators
-
Forestry Equipment
-
Forklifts
-
Generator Sets
-
Lifts
- View All Categories >>
-
- Biotech & Life Sciences
-
Biotechnology
-
Cell Counters
-
DNA Sequencers
-
DNA Synthesizers
-
Densitometers
-
Electrophoresis
-
Electroporation
-
Fermenters / Bioreactors
-
Flow Cytometers
-
Gel Dryer
-
Hybridization Ovens/Incubators
-
Immunoassay Systems
-
Microarray Scanners
-
Microplate Dispensers
- View All Categories >>
-
- Machinery
-
Abrasives
-
Air Compressors
-
Air Cooling & Heating Equipment
-
Bar Machinery
-
Bending & Forming Equipment
-
Boring Mills
-
Broaching Machines & Keyseaters
-
CNC Machinery
-
Chemical & Processing Equipment
-
Chip, Recycling & Scrap Equipment
-
Cleaning, Painting & Washing Equipment
-
Coil Processing Equipment
-
Construction Equipment
-
Die Casting Machines
- View All Categories >>
-
- Commercial Trucks
-
Heavy Duty Trucks
-
Medium Duty Trucks
-
Light Duty Trucks
-
Trailers
- View All Categories >>
-
- Chemical Equipment
-
AGITATORS
-
AIR FIN COOLERS
-
BLENDERS
-
BLOW MOLDERS
-
BLOWERS
-
BOILERS
-
CENTRIFUGES
-
COLUMNS
-
COLUMNS DBL DIA
-
COMPLETE PLANTS
-
COMPRESSORS
-
CONVERTERS
-
CONVEYORS
-
COOLING TOWERS
- View All Categories >>
-
- Apparel and Textile
-
Textile Machinery
-
Apparel & Textile Machinery Parts
-
Apparel Machinery
-
Home Textile Product Machinery
-
Apparel Accessories Machinery
-
Leather Production Machinery
- View All Categories >>
-
- Medical Equipment
-
Beds, Stretchers and Furniture
-
Cardiology
-
Consumables and Supplies
-
Cosmetic
-
Defibrillator
-
Dental
-
EMS/Rescue
-
Endoscopy
-
Exam Room
-
Homecare/Rehab
-
Imaging
-
Laboratory
-
Monitors/ICU/CCU
-
Neonatal
- View All Categories >>
-
- Printing Equipment
-
Press
-
Prepress
-
Postpress
-
Guillotines
-
Packaging
-
Misc
-
Flexo Printing
-
Web offset
-
Screen Printing
-
Package deals
-
Spare Parts
- View All Categories >>
-
- Packaging Equipment
-
Accumulators
-
Bag Dumps
-
Bag Sealers
-
Bagging Machines
-
Blister Packaging Lines
-
Blister Packers
-
Blister Sealers
-
Blow Fill Seal
-
Bottle Rinsers
-
Canning Equipment
-
Cap Sorters
-
Cappers
-
Cartoners
-
Case Erectors
- View All Categories >>
-
Reprogramming Fibroblasts into Oligodendrocyte Progenitor Cells May Lead to Cure for Multiple Sclerosis and Cerebral Palsy
05/14/2013 22:18:50
Working with mouse tissues, investigators have developed a method for converting skin or lung fibroblasts into fully functional oligodendrocytes, the type of cell responsible for myelinating the neurons of the brain and which are lost in myelin disorders such as multiple sclerosis and cerebral palsy.
Cell-based therapies for myelin disorders require technologies to generate functional oligodendrocyte progenitor cells (OPCs). In this regard, investigators at Case Western Reserve School of Medicine (Cleveland, OH, USA) described the direct conversion of mouse embryonic and lung fibroblasts to induced oligodendrocyte progenitor cells (iOPCs) using sets of either three or eight defined transcription factors.
They reported in the April 14, 2013, online edition of the journal Nature Biotechnology that the iOPCs exhibited a bipolar morphology and global gene expression profile consistent with bona fide OPCs. They could be expanded in vitro for at least five passages while retaining the ability to differentiate into multiprocessed oligodendrocytes. When transplanted to hypomyelinated mice, iOPCs were capable of ensheathing host axons and generating compact myelin.
“The myelin repair field has been hampered by an inability to rapidly generate safe and effective sources of functional oligodendrocytes,” said contributing author Dr. Robert Miller, professor of neurosciences at the Case Western Reserve School of Medicine. “The new technique may overcome all of these issues by providing a rapid and streamlined way to directly generate functional myelin producing cells.”
“It is cellular alchemy,” explained senior author Dr. Paul Tesar, assistant professor of genetics and genome sciences at Case Western Reserve School of Medicine. “We are taking a readily accessible and abundant cell and completely switching its identity to become a highly valuable cell for therapy.”
