Failure of Mutant Menin Protein to Block Hedgehog Signaling Triggers a Type of Endocrine Cancer

05/14/2013 22:25:30

Mutations in the gene that encodes the protein menin cause a hereditary cancer syndrome called MEN1 (multiple endocrine neoplasia type 1) due to the inability of the mutant menin protein to block the oncogenic effects of enhanced Hedgehog signaling.... ...

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Gene Regulatory-Network Maps Guide Alzheimer's Disease Researchers

05/14/2013 22:25:26

Researchers studying the molecular basis for development of neurological disorders have constructed a map of the gene-regulatory networks associated with late-onset Alzheimer¡¡¥s disease (LOAD).... ...

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Genome-Wide Analysis Pinpoints Cancer Cell Genes Linked to Metastasis and Chemotherapy Susceptibility

05/14/2013 22:25:02

Cancer researchers used genome-wide analyses to investigate the link between gene expression and anticancer compound sensitivity and cancer cell invasion.... ...

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How some cancers "Poison the Soil" to block metastasis

05/14/2013 22:24:56

Cancer spread or metastasis can strike unprecedented fear in the minds of cancer patients.... ...

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Ingenuity Systems Acquired by Qiagen, Adding Analysis, Interpretation of Complex Biologic Data Technology

05/14/2013 22:24:34

Qiagen NV (Hilden, Germany) has acquired Ingenuity Systems, Inc. (Redwood City, CA, USA), a leading provider of biomedical software that effectively analyzes and interprets the biologic meaning of genomic data.... ...

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Membrane remodelling: Where yoga meets cell biology

05/14/2013 22:24:02

Cells ingest proteins and engulf bacteria by a gymnastic, shape-shifting process called endocytosis. Researchers at the National Institutes of Health revealed how a key protein, dynamin, drives the action.... ...

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Molecular Signaling in the Hypothalamus Modulates the Aging Process

05/14/2013 22:23:25

A recent paper linked the aging process to molecular signals produced in the hypothalamus, a small region of the brain that is responsible for maintaining normal function for numerous bodily processes, including blood pressure, body temperature, and glucose levels.... ...

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Mouse Model Shows How a Gene Deletion Enables Regeneration of Adult Heart Muscle

05/14/2013 22:22:43

Researchers have identified a gene required by the embryo for heart development but found that its continued expression turned off the ability of mature heart muscle to regenerate.... ...

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Mutation That Blocks p53-Mediated DNA Repair Identified in Multiple Types of Cancer

05/14/2013 22:20:28

A mutation in the PPM1D (protein phosphatase, Mg2+/Mn2+ dependent, 1D) gene results in production of a C-terminally truncated form of the protein Wip1, which is a stable inhibitor of the p53 tumor suppressor.... ...

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Nematode Infection Controls Obesity and Modulates Body Weight and Metabolism

05/14/2013 22:19:46

In an interesting combination of low and high technology approaches to the control and treatment of obesity, a recent study suggested that infection with parasitic nematodes (roundworms) could suppress the chronic inflammation associated with obesity and modulate body weight and metabolism.... ...

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